Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 43, Issue 3-4, Pages 81-92Publisher
BIOSCIENTIFICA LTD
DOI: 10.1677/JME-08-0123
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Funding
- Research Grant Council HKU [7501/05 M, 7566/06]
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The maintenance of body water homeostasis depends on the balance between water intake and water excretion. In the kidney, vasopressin (Vp) is a critical regulator of water homeostasis by controlling the insertion of aquaporin 2 (AQP2) onto the apical membrane of the collecting duct principal cells in the short term and regulating the gene expression of AQP2 in the long term. A growing body of evidence from both in vitro and in vivo studies demonstrated that both secretin and oxytocin are involved as Vp-independent mechanisms regulating the renal water reabsorption process, including the translocation and expression of AQP2. This review focuses on how these two hormones are potentially involved as Vp-independent mechanisms in controlling water homeostasis. Journal of Molecular Endocrinology (2009) 43, 81-92
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