Journal
JOURNAL OF MOLECULAR DIAGNOSTICS
Volume 14, Issue 5, Pages 419-423Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jmoldx.2012.03.007
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- Intramural NIH HHS Funding Source: Medline
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Matrix-assisted laser desorption/ionization time-of flight (MALDI-TOF) mass spectrometry (MS) offers the possibility of accurate, rapid, inexpensive identification of bacteria, fungi, and mycobacteria isolated in clinical microbiology laboratories. The procedures for preanalytic processing of organisms and analysis by MALDI-TOF MS are technically simple and reproducible, and commercial databases and interpretive algorithms are available for the identification of a wide spectrum of clinically significant organisms. Although only limited work has been reported on the use of this technique to identify molds, perform strain typing, or determine antibiotic susceptibility results, these are fruitful areas of promising research. As experience is gained with MALDI-TOF MS, it is expected that the databases will be expanded to resolve many of the current inadequate identifications (eg, no identification, genus-level identification) and algorithms for potential misidentification will be developed.. The current lack of Food and Drug Administration approval of any MALDI-TOF MS system for organism identification limits widespread use in the United States. (J Mol Dian 2012, 14:419-423; http://dx.doi.org/10.1016/j.jmoldx.2012.03.007)
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