Journal
JOURNAL OF MOLECULAR DIAGNOSTICS
Volume 10, Issue 1, Pages 13-27Publisher
ELSEVIER SCIENCE INC
DOI: 10.2353/jmoldx.2008.070082
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Funding
- NATIONAL CANCER INSTITUTE [P01CA087969, P01CA055075] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA55075, P01 CA055075, P01 CA087969, P01 CA87969] Funding Source: Medline
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Molecular classification of colorectal cancer is evolving. As our understanding of colorectal carcinogenesis improves, we are incorporating new knowledge into the classification system. In particular, global genomic status [microsatellite instability (MSI) status and chromosomal instability (CIN) status] and epigenomic status [CpG island methylator phenotype (CIMP) status] play a significant role in determining clinical, pathological and biological characteristics of colorectal cancer. in this review, we discuss molecular classification and molecular correlates based on MSI status and CIMP status in colorectal cancer. Studying molecular correlates is important in cancer research because it can 1) provide clues to pathogenesis, 2) propose or support the existence of a new molecular subtype, 3) alert investigators to he aware of potential confounding factors in association studies, and 4) suggest surrogate markers in clinical or research settings.
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