Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 70, Issue 3-4, Pages 101-107Publisher
ELSEVIER
DOI: 10.1016/j.molcatb.2011.02.011
Keywords
2-Fluoro-2-alken-1-ols; Saccharomyces cerevisiae; Biocatalytic reduction
Funding
- National Natural Science Foundation of China [20872041]
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Biocatalytic reduction of 2-fluoro-2-alken-1-ols mediated by Saccharomyces cerevisiae underwent smoothly and yielded (S)-2-fluorinated alkanols with high enantioselectivities. The conversion rate was markedly depending on the configuration of alkene moiety of the substrate, the chain length of alkyl group at beta position of C=C bond, as well as the reaction conditions. (C) 2011 Elsevier B.V. All rights reserved.
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