Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 57, Issue 1-4, Pages 34-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcatb.2008.06.013
Keywords
Immobilized lipase; Non-aqueous media; Kinetics; Mechanism; Esterfication; Cinnamyl laurate
Funding
- Department of Biotechnology, Govt. of India
- Darbari Seth Professorship Endowment
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Esters of cinnamyl alcohol find many applications in food, cosmetic and pharmaceutical industries as flavor and fragrance compounds. The current work focuses on the synthesis of cinnamyl laurate from cinnamyl alcohol and lauric acid, including screening of various immobilized lipases and optimization of reaction conditions such as catalyst loading, speed of agitation, mole ratio and temperature. Among different lipases screened such as Novozym 435, Lipozyme RM IM and Lipozyme TLIM, Novozym 435 was found to be the best catalyst with 60% conversion in 2 h at 30 degrees C for equimolar quantities of the reactants using 0.33% (w/v) of catalyst and toluene as solvent. An ordered bi-bi mechanism with dead-end complex of lauric acid was found to represent the kinetic data. (c) 2008 Published by Elsevier B.V.
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