Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 60, Issue 3-4, Pages 191-194Publisher
ELSEVIER
DOI: 10.1016/j.molcatb.2009.05.006
Keywords
Transamination; Dynamic kinetic resolution; Asymmetric synthesis; omega-Transaminases; Co-solvent
Funding
- FFG
- Province of Styria
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Enantiomerically enriched 4-phenylpyrrolidin-2-one was prepared within only three steps starting from a commercial compound employing dynamic kinetic resolution (DKR) as the key asymmetric step. To the best of our knowledge, for the first time a DKR was performed involving an enzymatic enantioselective amination reaction catalyzed by omega-transaminases. Careful optimization of co-solvent and pH conditions allowed enhancing the enantioselectivity. The general method allows access to 4-arylpyrrolidin-2-ones derivatives, the cyclic analogues of gamma-aminobutyric acid (GABA) derivatives. (C) 2009 Elsevier B.V. All rights reserved.
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