Journal
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
Volume 361, Issue -, Pages 36-44Publisher
ELSEVIER
DOI: 10.1016/j.molcata.2012.04.014
Keywords
Asymmetric oxidation; Sulfoxidation; Schiff base; Chiral titanium complex; Hydrogen peroxide
Categories
Funding
- UGC
- DST
- CSIR Network Project on Catalysis
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An efficient asymmetric oxidation of prochiral sulfides catalyzed by a series of simple in situ generated complexes based on chiral amino alcohol derived Schiff bases with Ti(Oi-Pr)(4) was carried out in presence of cheap and environmentally benign oxidant H2O2 at 0 degrees C. Prochiral sulfides were converted to respective chiral sulfoxides efficiently (conversion, 93%; up to ee, 98%) with this system in 10 h at 0 degrees C. The present study demonstrated a significant role of steric influence of the substituent attached on both aryl and alkyl moiety on the enantioselectivity. Kinetic studies of the catalytic reaction showed first order dependence on substrate and catalyst whereas it is zero for the oxidant. Kinetic studies in combination with UV-vis. spectral studies were used to propose a catalytic cycle for the sulfoxidation reaction. (c) 2012 Elsevier B.V. All rights reserved.
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