Journal
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
Volume 296, Issue 1-2, Pages 54-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcata.2008.09.008
Keywords
Primidone; Salen complex; Metalloporphyrin; Catalysis; Biomimetic models; Jacobsen catalyst
Categories
Funding
- FAPESP
- CAPES
- CNPq
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Primidone (PRM) oxidation by various oxidants such as iodosylbenzene (PhIO), tert-butyl hydroperoxide 70wt.% (t-BOOH), 3-chloroperoxybenzoic acid (m-CPBA) and hydrogen peroxide 30wt.%, mediated by either a salen complex or metalloporphyrins, was investigated. The catalytic systems led to phenylethyl-malondiamide (PEMA) and phenobarbital (FEND), the same metabolites obtained in vivo with P450 enzymes, although three other products were also detected. Product formation was highly dependent on the oxidant, co-catalyst (imidazole), pH and dioxygen. These biomimetic chemical models have potential application in the synthesis of drug metabolites. which should provide samples for pharmacological tests. They can also be employed in studies that pursue the elucidation of in vivo drug metabolism. (C) 2008 Elsevier B.V. All rights reserved.
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