Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 404, Issue 3, Pages 372-380Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2010.09.019
Keywords
olfaction; odorant-binding proteins; kinetics; mass spectrometry
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Funding
- Biotechnology and Biological Sciences Research Council (UK) [BBD5228701]
- Biotechnology and Biological Sciences Research Council [BB/D522870/1] Funding Source: researchfish
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We have measured the effect of rat odorant-binding protein 1 on the rates of ligand uptake and liquid-to-air transfer rates with a set of defined odorous compounds. Comparison of observed rate constants (k(obs)) with data simulated over a wide range of different kinetic and thermodynamic regimes shows that the data do not agree with the previously held view of a slow off-rate regime (k(off) <0.0004 s(-1)). We propose that a rapid koff would be a necessary requirement for such a system, since slow odorant-release rates would result in significant decorrelation between the olfactory world and odour perception. (c) 2010 Elsevier Ltd. All rights reserved.
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