Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 401, Issue 5, Pages 681-689Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2010.06.058
Keywords
SMN; gemins; RNA granules; SMA
Categories
Funding
- Vandervell Foundation
- IBCS/PMS
- SMA Trust
- Northcott Medical Foundation
- Fight-SMA
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Childhood spinal muscular atrophy is caused by a reduced expression of the survival motor neuron (SMN) protein. SMN has been implicated in the axonal transport of beta-actin mRNA in both primary and transformed neuronal cell lines, and loss of this function could account, at least in part, for spinal muscular atrophy onset and pathological specificity. Here we have utilised a targeted screen to identify mRNA associated with SMN, Gemin2 and Gemin3 in the cytoplasm of a human neuroblastoma cell line, SHSY5Y. Importantly, we have provided the first direct evidence that beta-actin mRNA is present in SMN cytoplasmic complexes in SHSY5Y cells. (C) 2010 Elsevier Ltd. All rights reserved.
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