Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 71, Issue -, Pages 71-80Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2013.10.014
Keywords
Autophagy; Apoptosis; Diabetic cardiomyopathy; AMPK
Categories
Funding
- NIH [1P20RR024215-01]
- American Heart Association
- Oklahoma Center for Advancement of Science and Technology
Ask authors/readers for more resources
Diabetic cardiomyopathy is characterized by ventricular dysfunction that occurs in diabetic patients independent of coronary artery disease, hypertension, and any other cardiovascular diseases. Diabetic cardiomyopathy has become a major cause of diabetes-related mortality. Thus, an urgent need exists to clarify the mechanism of pathogenesis. Emerging evidence demonstrates that diabetes induces cardiomyocyte apoptosis and suppresses cardiac autophagy, indicating that the interplay between the autophagy and apoptotic cell death pathways is important in the pathogenesis of diabetic cardiomyopathy. This review highlights recent advances in the crosstalk between autophagy and apoptosis and its importance in the development of diabetic cardiomyopathy. This article is part of a Special Issue entitled Protein Quality Control, the Ubiquitin Proteasome System, and Autophagy. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available