Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 73, Issue -, Pages 34-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2013.12.032
Keywords
Monoamine oxidase; Oxidative stress; Mitochondrial dysfunction; Heart failure; Ischemia/reperfusion injury
Categories
Funding
- COST Action EU-ROS [BM1203]
- Fondazione Cariparo
- NIH [R01HL075265, R01HL091923]
- AHA [17070027]
- Agence Nationale pour la Recherche (ANR)
- Region Midi-Pyrenees
- INSERM, Institut National pour la Sante Et la Recherche Medicale, France
- National Research Council of Italy
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Oxidative stress can be generated at several sites within the mitochondria. Among these, monoamine oxidase (MAO) has been described as a prominent source. MAOs are mitochondrial flavoenzymes responsible for the oxidative deamination of catecholamines, serotonin and biogenic amines, and during this process they generate H2O2 and aldehyde intermediates. The role of MAO in cardiovascular pathophysiology has only recently gathered some attention since it has been demonstrated that both H2O2 and aldehydes may target mitochondrial function and consequently affect function and viability of the myocardium. In the present review, we will discuss the role of MAO in catecholamine and serotonin clearance and cycling in relation to cardiac structure and function. The relevant contribution of each MAO isoform (MAO-A or -B) will be discussed in relation to mitochondrial dysfunction and myocardial injury. Finally, we will examine both beneficial effects of their pharmacological or genetic inhibition along with potential adverse effects observed at baseline in MAO knockout mice, as well as the deleterious effects following their over-expression specifically at cardiomyocyte level. This article is part of a Special Issue entitled Redox Signalling in the Cardiovascular System. (c) 2014 Elsevier Ltd. All rights reserved.
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