Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 70, Issue -, Pages 64-73Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2014.01.013
Keywords
Cardiac fibroblast; Cardiac hypertrophy; Fibroblast growth factor signaling; Notch signaling; Thrombospondin-1 signaling; S100A4
Categories
Funding
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)
- Japan Society for the Promotion of Science (JSPS)
- JSPS [23390203, 20390220, 22229006, 23790835]
- Japan Science and Technology (JST)
- Grants-in-Aid for Scientific Research [23390203, 22229006, 20390220, 23790835, 26461125] Funding Source: KAKEN
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Under normal physiological conditions, cardiac fibroblasts are the primary producers of extracellular matrix and supply a mechanical scaffold for efficacious heart contractions induced by cardiomyocytes. In the hypertrophic heart, cardiac fibroblasts provide a pivotal contribution to cardiac remodeling. Many growth factors and extracellular matrix components secreted by cardiac fibroblasts induce and modify cardiomyocyte hypertrophy. Recent evidence revealed that cardiomyocyte-cardiac fibroblast communications are complex and multifactorial. Many growth factors and molecules contribute to cardiac hypertrophy via different roles that include induction of hypertrophy and the feedback hypertrophic response, fine-tuning of adaptive hypertrophy, limitation of left ventricular dilation, and modification of interstitial changes. This review focuses on recent work and topics and provides a mechanistic insight into cardiomyocyte-cardiac fibroblast communication in cardiac hypertrophy. This article is part of a Special Issue entitled Myocyte-Fibroblast Signalling in Myocardium . (C) 2014 Elsevier Ltd. All rights reserved.
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