Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 64, Issue -, Pages 90-98Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2013.09.006
Keywords
Dephosphorylation; Protein phosphatases; Heart failure; Atrial fibrillation
Categories
Funding
- Deutsche Forschungsgemeinschaft [Do 769/1-1-3, EL 270/3-1/2, SFB 1002 TP A02]
- European Network for Translational Research in Atrial Fibrillation [261057]
- German Heart Foundation
- European-North American Atrial Fibrillation Research Alliance grant of Fondation Leducq [07CVD03]
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Protein phosphorylation is a major control mechanism of a wide range of physiological processes and plays an important role in cardiac pathophysiology. Serine/threonine protein phosphatases control the dephosphorylation of a variety of cardiac proteins, thereby fine-tuning cardiac electrophysiology and function. Specificity of protein phosphatases type-1 and type-2A is achieved by multiprotein complexes that target the catalytic subunits to specific subcellular domains. Here, we describe the composition, regulation and target substrates of serine/threonine phosphatases in the heart. In addition, we provide an overview of pharmacological tools and genetic models to study the role of cardiac phosphatases. Finally, we review the role of protein phosphatases in the diseased heart, particularly in ventricular arrhythmias and atrial fibrillation and discuss their role as potential therapeutic targets. (C) 2013 Elsevier Ltd. All rights reserved.
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