Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 58, Issue -, Pages 217-224Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2012.12.009
Keywords
Dystrophic cardiomyopathy; Excitation-contraction coupling; Ryanodine receptor; Ca2+ signals
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Funding
- NIH [HL093342, AR053933]
- SNF [31-132689, 31-109693]
- Swiss Foundation for Research on Muscle Diseases
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Dilated cardiomyopathy is a serious and almost inevitable complication of Duchenne Muscular Dystrophy, a devastating and fatal disease of skeletal muscle resulting from the lack of functional dystrophin, a protein linking the cytoskeleton to the extracellular matrix. Ultimately, it leads to congestive heart failure and arrhythmias resulting from both cardiac muscle fibrosis and impaired function of the remaining cardiomyocytes. Here we summarize findings obtained in several laboratories, focusing on cellular mechanisms that result in degradation of cardiac functions in dystrophy. This article is part of a Special Issue entitled Calcium Signaling in Heart. (C) 2012 Elsevier Ltd. All rights reserved.
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