Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 58, Issue -, Pages 125-133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2012.12.021
Keywords
Excitation-contraction coupling; Heart; Intracellular calcium; Mitochondrial Ca transport; Ca buffering
Categories
Funding
- National Institutes of Health [HL62231, HL80101, HL101235]
- Leducq Foundation
- American Heart Association [AHA 0735071N]
- Rush University Medical Center [31196]
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Mitochondrial Ca signaling contributes to the regulation of cellular energy metabolism, and mitochondria participate in cardiac excitation-contraction coupling (ECC) through their ability to store Ca, shape the cytosolic Ca signals and generate ATP required for contraction. The mitochondrial inner membrane is equipped with an elaborate system of channels and transporters for Ca uptake and extrusion that allows for the decoding of cytosolic Ca signals, and the storage of Ca in the mitochondrial matrix compartment. Controversy, however remains whether the fast cytosolic Ca transients underlying ECC in the beating heart are transmitted rapidly into the matrix compartment or slowly integrated by the mitochondrial Ca transport machinery. This review summarizes established and novel findings on cardiac mitochondrial Ca transport and buffering, and discusses the evidence either supporting or arguing against the idea that Ca can be taken up rapidly by mitochondria during ECC. This article is part of a Special Issue entitled Calcium Signaling in Heart. (C) 2013 Elsevier Ltd. All rights reserved.
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