Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 58, Issue -, Pages 118-124Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2012.11.014
Keywords
Ca2+ waves; Mathematical models; Ca2+ sparks; Arrhythmias
Categories
Funding
- NIH [R01 HL090880, R03 AG031944]
- University of California, Davis
Ask authors/readers for more resources
Ca2+ waves were probably first observed in the early 1940s. Since then Ca2+ waves have captured the attention of an eclectic mixture of mathematicians, neuroscientists, muscle physiologists, developmental biologists, and clinical cardiologists. This review discusses the current state of mathematical models of Ca2+ waves, the normal physiological functions Ca2+ waves might serve in cardiac cells, as well as how the spatial arrangement of Ca2+ release channels shape Ca2+ waves, and we introduce the idea of Ca2+ phase waves that might provide a useful framework for understanding triggered arrhythmias. This article is part of a Special Issue entitled Calcium Signaling in Heart. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available