Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 52, Issue 2, Pages 366-375Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2011.07.007
Keywords
Caveolae; G protein coupled receptor; Cyclic AMP; Nitric oxide; Calcium; Compartmentation
Categories
Funding
- Medical Research Council
- British Heart Foundation
- National Institutes of Health
- American Heart Association
- MRC [G0700889] Funding Source: UKRI
- British Heart Foundation [PG/09/051/27828] Funding Source: researchfish
- Medical Research Council [G0700889] Funding Source: researchfish
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Compartmentation of signalling allows multiple stimuli to achieve diverse cellular responses with only a limited pool of second messengers. This spatial control of signalling is achieved, in part, by cellular structures which bring together elements of a particular cascade. One such structure is the caveola, a flask-shaped lipid raft. Caveolae are well-recognised as signalosomes, platforms for assembly of signalling complexes of receptors, effectors and their targets, which can facilitate efficient and specific cellular responses. Here we extend this simple model and present evidence to show how the protein and lipid profiles of caveolae, as well as their characteristic morphology, define their roles in creating local signalling domains in the cardiac myocyte. This article is part of a Special Issue entitled Local Signaling in Myocytes. (C) 2011 Elsevier Ltd. All rights reserved.
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