Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 52, Issue 6, Pages 1203-1212Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2012.03.012
Keywords
Cardiomyocytes; Differentiation; Growth factors; Stem cells; Small molecules
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Human cardiomyocytes derived from pluripotent stem cells hold great promise for cardiac cell therapy, disease modeling, drug discovery, and the study of developmental biology. Reaching these potentials fully requires the development of methods that enable efficient and robust generation of cardiomyocytes with expected characteristics. This review summarizes and discusses up-to-date methods that have been used to derive and enrich human cardiomyocytes from pluripotent stem cells, provides a brief overview of in vitro and in vivo characterization of these cardiomyocytes, and considers future advancement needed to further harness the power of these cells. (C) 2012 Elsevier Ltd. All rights reserved.
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