Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 48, Issue 3, Pages 550-557Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.yjmcc.2009.06.013
Keywords
Regenerative healing; Skin; Heart; Wound repair; Myocardial infarction; TGF-beta; Connexin 43; Stem cell; Gap junction
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F30HL095320, R01HL082802, R01HL056728] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R41AR053798] Funding Source: NIH RePORTER
- NHLBI NIH HHS [F30 HL095320-04, R01 HL082802-04, R01 HL056728-07, R01 HL082802-01, F30 HL095320-03, F30 HL095320, R01 HL056728-08, R01 HL056728-06, R01 HL082802-02, R01 HL056728, F30 HL095320-01, R01 HL082802, R01 HL056728-09, F30 HL095320-02, R01 HL082802-03] Funding Source: Medline
- NIAMS NIH HHS [R41 AR053798-01, R41 AR053798] Funding Source: Medline
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Regenerative healing is the process by which injured tissues are restored to their original structure and function. Many species are capable of healing in this manner. However, in mammals the healing response in most tissues is marked by fibroblast proliferation and scar tissue deposition. While scarring contributes to efficient resolution of mammalian wounds and restoration of at least partial structural and functional support, the final result of scar formation can be more deleterious than the initial insult. This is especially true in the heart, which is sensitive to electrical heterogeneities and altered mechanical properties produced by scarring. Several therapeutic modalities promoting regeneration in skin wounds have been developed that modulate various aspects of the healing process. Targets include cytokine stimulation, control of fibroblast activation, modulation of gap junctions, and stem cell differentiation. Here, we review and compare mechanisms of injury, repair, and scarring in the skin and heart and discuss the promise and caveats of future therapies that may translate to improving repair of myocardial tissues. (C) 2009 Elsevier Ltd. All rights reserved.
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