Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 46, Issue 6, Pages 811-820Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2009.02.023
Keywords
Mitochondria; Mitochondrial fission and fusion; Mitochondrial dynamics; Cardiac muscle; Ventricular myocytes
Categories
Funding
- National Institute of Health [HL33333]
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Mitochondria play a critical role in cellular energy metabolism, Ca2+ homeostasis, reactive oxygen species generation, apoptosis, aging, and development. Many recent publications have shown that a continuous balance of fusion and fission of these organelles is important in maintaining their proper function. Therefore, there is a steep correlation between the form and function of mitochondria. Many major proteins involved in mitochondrial fusion and fission have been identified in different cell types, including heart. However, the functional role of mitochondrial dynamics in the heart remains, for the most part, unexplored. In this review we will cover the recent field of mitochondrial dynamics and its physiological and pathological implications, with a particular emphasis on the experimental and theoretical basis of mitochondrial dynamics in the heart. Published by Elsevier Inc.
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