Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 44, Issue 5, Pages 855-864Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2008.03.008
Keywords
insulin; IGF; cardiac growth; signal transduction; signaling; diabetes; diabetic cardiomyopathy; heart failure; hypertrophy
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Funding
- NHLBI NIH HHS [HL61567, R01 HL076670-04, T32 HL007873, T32-HL07873, P01 HL057278, HL057278, P01 HL057278-100006, R01 HL061567-09, HL076670, R01 HL076670, R01 HL061567] Funding Source: Medline
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The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed. Published by Elsevier Inc.
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