Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 45, Issue 4, Pages 495-504Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2008.02.273
Keywords
Notch; Jagged; Delta-like; Heart; Cardiac stem cells; Differentiation; Knockout
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Funding
- Swiss National Foundation
- Leenaards Foundation, Lausanne, Switzerland
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In the developing heart, Notch signaling plays an essential role in several key developmental processes, such as epithelial-to-mesenchymal transition and myocyte proliferation and differentiation. The importance of Notch in cardiac development has been demonstrated in knockout mice carrying null mutations in genes encoding components of the Notch pathway. Furthermore, humans with inactivating mutations in the Notch ligand Jagged1 suffer from Alagille syndrome, a condition characterized by several cardiac defects. Notch l receptor haploinsufficiency has also been involved in aortic valve disease in humans. In addition, accumulating evidence indicates that Notch may also regulate homeostasis in the adult heart. Notch may protect the heart from an excessive and detrimental hypertrophic response and increase cardiomyocyte survival. Emerging evidence also suggests that Notch could be important for cardiac tissue renewal by controlling the maintenance and commitment of a cardiac stem cell compartment. (C) 2008 Elsevier Inc. All rights reserved.
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