Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 45, Issue 1, Pages 11-27Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2008.03.025
Keywords
chaperones; ubiquitin; proteasome; autophagy; proteases; signal transduction
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Funding
- NHLBI NIH HHS [R01 HL085629, R01 HL072166-02, R01 HL072166-03, R01HL072166, R01 HL072166-04, R01 HL072166, R01 HL085629-02, R01 HL085629-01, R01 HL072166-01A1, R01HL085629, R01 HL072166-05] Funding Source: Medline
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The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure. (C) 2008 Elsevier Inc. All rights reserved.
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