Journal
JOURNAL OF MICROSCOPY
Volume 251, Issue 1, Pages 1-4Publisher
WILEY-BLACKWELL
DOI: 10.1111/jmi.12054
Keywords
Chromatin; DNA imaging; fluorescence labelling; super-resolution
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Funding
- Spanish Ministerio de Economia y Competitividad [RYC-2011-07637, MAT-2012-34487]
- European Comission [303620]
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Super-resolution fluorescence microscopy is ideally suited to study the complex organization of cell DNA in the 10-100 nm range. Novel methods to image directly labelled DNA, instead of DNA-associated proteins, are being developed and refined. This minireview provides an update of recent progress in super-resolution fluorescence imaging methods for DNA. These developments should allow a deeper understanding of chromatin structure and widen the scope of biological processes that may be investigated with super-resolution fluorescence microscopy.
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