Journal
JOURNAL OF MICROENCAPSULATION
Volume 32, Issue 2, Pages 129-136Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2014.950712
Keywords
4-(1-pyrenyl) butyric acid; cellar imaging; controlled release; fluorescent microspheres; ZnO QDs
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [51072167, 31370966]
Ask authors/readers for more resources
Growth factor-loaded fluorescent alginate microspheres, which can realise sustained growth factor release and fluorescence imaging, were synthesised by in situ formation of ZnO quantum dots (QDs) and covalent graft of 4-(1-pyrenyl) butyric acid (PBA). BSA was chosen as a growth factor model protein to study the release kinetic of growth factors from alginate microspheres. The microsphere size and fluorescent properties were also investigated. Investigations of cell culture were used for evaluating biocompatibility of BSA-loaded fluorescent microspheres and fluorescence imaging property of ZnO QDs and PBA-grafted sodium alginate from the microspheres. The results show that they have good fluorescent property either to microspheres or to cells and fluorescent microspheres have good biocompatibility and property in sustained release of growth factors. The obtained microspheres will be expected to realise the imaging of cells and materials and also the release of growth factor in tissue engineering or in cell culture.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available