Journal
JOURNAL OF MICROENCAPSULATION
Volume 30, Issue 7, Pages 692-700Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2013.778906
Keywords
High-shear mixer; rheological behaviour; solid dispersion; ultrasound
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP - 08/02848-9, 08/07115-0]
- CNPq [PQ-2]
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The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire (R) 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (499%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D-90) to 62.8 +/- 4.1 mu m and 64.9 +/- 3.3 mu m, respectively, while magnetic stirring produced microparticles with a size of 84.1 +/- 1.4 mu m. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation.
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