Journal
JOURNAL OF MICROENCAPSULATION
Volume 30, Issue 5, Pages 490-497Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2012.752537
Keywords
microparticles; electrospray; controlled release; drug delivery
Funding
- National Basic Research Program of China [2012CB933900]
- International Science and Technology Cooperation Program [2010DFA51500]
- National Natural Science Foundation of China [51073016, 81171000]
- Program for New Century Excellent Talents in University [NCET-11-0556]
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Biodegradable poly (lactic-co-glycolic acid) (PLGA) microparticles are an effective way to achieve sustained drug release. In this study, we investigated a sustained release model of PLGA microparticles with incorporated protein via either emulsion or coaxial electrospray techniques. PLGA (75:25) was used as the carrier, and bovine serum albumin as a model protein. Coaxial electrospray resulted in a type of core-shell structure with mean diameters of 2.41 +/- 0.60 mu m and a centralised protein distribution within the core. Emulsion electrospray formed bigger microparticles with mean diameters of 22.75 +/- 8.05 mu m and a heterogeneous protein distribution throughout the microparticles. The coaxial electrospray microparticles presented a much slighter burst release than the emulsion electrospray microparticles. Loading efficiency was significantly higher (p < 0.05) in the coaxial group than emulsion group. This indicated that both emulsion and coaxial electrospray could produce protein-loaded microparticles with sustained release behaviour, but the former revealed a superior approach for drug delivery.
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