Journal
JOURNAL OF MICROENCAPSULATION
Volume 28, Issue 1, Pages 74-81Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652048.2010.529948
Keywords
Ibuprofen; solid lipid nanoparticles; high-pressure homogenization; cytotoxicity
Funding
- EPSRC [EP/E036244/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E036244/1] Funding Source: researchfish
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Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.
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