Journal
JOURNAL OF MICROENCAPSULATION
Volume 26, Issue 8, Pages 722-733Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/02652040902726994
Keywords
Phosphatidylcholine (lecithin); chitosan; alginic acid; electronic attraction; nano liposome; carrier system
Funding
- Ministry of Agriculture and Forestry project, Republic of Korea
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Nano carrier systems were prepared by forming self-assembled liposomes having a size distribution in the nano range through use of an ultrasonic homogenizer. Phosphatidylcholine and cholesterol were utilized as an amphiphilic compound and a shape stabilizer, respectively. The size of prepared samples was decreased (up to 150 nm) by elevating ratio of lecithin and extending homogenization time (2 similar to 6 min). After secondary coating with alginic acid (0.1, 0.3 and 0.5%, W/V), size was remarkably changed in the range of +/-30nm and zeta-potential was altered (only chitosan coating (molecular weight: 30 000 Da, 0.2%, W/V): 10.3 mV, Alginic acid coating (0.5%, W/V) after the chitosan coating: -21.8 mV). The low molecular weight chitosan (0.1%, W/V)-coated nano-liposomes had a lower absolute value of zeta-potential than the high molecular weight chitosan (0.1%, W/V)coated nano-liposomes. The encapsulation efficiency was measured by gas chromatography. The efficiency was decreased slightly by elevating chitosan concentration (0.1 similar to 0.5%, W/V).
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