Journal
JOURNAL OF MICROENCAPSULATION
Volume 26, Issue 1, Pages 46-53Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02652040802130503
Keywords
Metformin hydrochloride; microspheres; non-solvent addition; emulsion solvent evaporation; in vitro; in vivo
Ask authors/readers for more resources
The objectives of this investigation were to prepare microspheres of the anti-diabetic drug, metformin hydrochloride, using ethyl cellulose as the polymer and evaluate the encapsulation efficiency and release characteristics in vitro and in vivo; utilizing different microencapsulation techniques. Different proportions of polymer were used to obtain varying drug-polymer ratios. Physical properties, loading efficiency and dissolution rate were dependent on the method chosen for preparation and also on the drug-to-polymer ratio. The addition of surfactant during emulsification and petroleum ether in non-solvent addition process affected release of drug and also size distribution of microspheres. To investigate the type of mechanism that occurs, dissolution data were plotted according to different kinetic models. In vitro release studies show first order and Higuchi model release characteristics being exhibited. All the results were treated statistically to validate the findings. Significant differences in percentage yield, entrapment efficiency and sustaining capacity were seen with microspheres prepared by two different methods. In vivo studies in normal and hyperglycemic mice show faster glucose reduction with microspheres prepared by the evaporation method, whereas the release sustaining effect was more pronounced with microspheres prepared by the non-solvent addition method.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available