Journal
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume 22, Issue 1, Pages 80-83Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1108.08069
Keywords
5-Bromotoluhydroquinone; gentisyl alcohol; 4-O-methyltoluhydroquinone; toluhydroquinone; Dothideomycete sp.
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Funding
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2008-314-F00048]
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The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5-bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures of 1 and 2 were assigned through the spectroscopic data analyses. Compounds 1-4 showed a potent antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC (minimum inhibitory concentration) values of 6.2, 12.5, 6.2, and 12.5 mu g/ml, respectively. Compounds 1-4 also exhibited a moderate radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values of 11.0, 17.0, 12.0, and 7.0 mu M, respectively, which were more active than the positive control, L-ascorbic acid (IC50, 20.0 mu M).
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