Journal
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume 22, Issue 11, Pages 1478-1481Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1206.06026
Keywords
Geldanamycin; natural products; biosynthetic shunt product
Categories
Funding
- 21C Frontier MGAC
- Global R&D Center Program
- Global Frontier Project (ISBC) [2011-0031947]
- NRF
- Next-Generation BioGreen 21 Program (SSAC) [PJ007999]
- RDA, Republic of Korea
Ask authors/readers for more resources
Geldanamycin (GM) and its analogs are important anticancer agents that inhibit heat shock protein (Hsp) 90, which is a major chaperone protein in cancer cells. Accordingly, based on interest in obtaining novel natural GM derivatives, the potential of Streptomyces hygroscopicus JCM4427, a GM producer, was explored for novel natural GM derivative(s), resulting in the discovery of new GM analogs as a biosynthetic shunt product and intermediates from its fermentation broth. In this study, the fermentation, isolation, structure determination, and biological activity of the compounds, two new tetracyclic thiazinogeldanamycin (1) and 19-hydroxy-4,5-dihydrogeldanamycin (3), together with the three known 4,5-dihydrothiazinogeldanamycin (2), reblastatin (4), and 17-demethoxy-reblastatin (5), are described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available