Journal
JOURNAL OF MICROBIOLOGY
Volume 51, Issue 4, Pages 527-530Publisher
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-013-3087-8
Keywords
glyoxal; methylglyoxal; aldo-keto reductase
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Funding
- Korea Institute of Planning and Evaluation for Technology in food, agriculture, forestry, and fisheries [110056032HD120]
- National Research Foundation of Korea [N01120620]
- National Research Foundation of Korea [2012R1A1A2041712] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Glyoxal (GO) and methylglyoxal (MG) are reactive carbonyl compounds that are accumulated in vivo through various pathways. They are presumably detoxified through multiple pathways including glutathione (GSH)-dependent/independent glyoxalase systems and NAD(P)H dependent reductases. Previously, we reported an involvement of aldo-ketoreductases (AKRs) in MG detoxification. Here, we investigated the role of various AKRs (YqhE, YafB, YghZ, YeaE, and YajO) in GO metabolism. Enzyme activities of the AKRs to GO were measured, and GO sensitivities of the corresponding mutants were compared. In addition, we examined inductions of the AKR genes by GO. The results indicate that AKRs efficiently detoxify GO, among which YafB, YghZ, and YeaE are major players.
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