Journal
JOURNAL OF MICROBIOLOGY
Volume 47, Issue 3, Pages 337-343Publisher
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-009-0125-7
Keywords
mRNA export; Schizosaccharomyces pombe; nup211
Categories
Funding
- Korean Government (MOEHRD) [KRF-2006-312-C00380]
Ask authors/readers for more resources
Synthetic lethal mutants have been previously isolated in fission yeast Schizosaccharomyces pombe, which genetically interact with spmex67, in order to identify the genes involved in mRNA export. The nup211 gene was isolated by complementation of the growth defect in one of the synthetic lethal mutants, SLMex2, under synthetic lethal condition. We showed that Nup211, fission yeast homolog of Mlpl/Mlp2/Tpr, is essential for vegetative growth and Nup211-GFP proteins expressed at endogenous level are localized mainly in nuclear periphery. The accumulation of poly(A)(+) RNA in the nucleus is exhibited when expression of nup211 is repressed or over-expressed. These results suggest that the Nup211 protein plays a pivotal role of mRNA export in fission yeast.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available