Journal
JOURNAL OF MEDICINAL FOOD
Volume 15, Issue 1, Pages 96-99Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/jmf.2011.1636
Keywords
cerebral cortex; dopaminergic neuron; ischemia; Mycoleptodonoides aitchisonii
Funding
- Shizuoka Prefecture
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23500963] Funding Source: KAKEN
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We performed a transient bilateral common carotid artery occlusion on rats and investigated whether feeding an aqueous extract of Mycoleptodonoides aitchisonii, an edible mushroom, affected metabolism of monoamines in the cerebral cortex, possibly protecting against ischemic damage. Seventeen days after the surgery, concentrations of the dopamine (DA) metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and of homovanillic acid (HVA) in the cerebral cortex of the M. aitchisonii fed group (MV) were higher than in the control ischemia (CV) group. The turnover rate of DA, which was indicated by (DOPAC + HVA)/DA, for the CV group was significantly lower than for the MV group, and the MV group value was the same rate as the sham-operated group. These data indicate that M. aitchisonii affects the dopaminergic neuronal system following brain ischemia damage in the cerebral cortex.
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