Supplementation of Cheonggukjang and Red Ginseng Cheonggukjang Can Improve Plasma Lipid Profile and Fasting Blood Glucose Concentration in Subjects with Impaired Fasting Glucose

This study was conducted to investigate the plasma lipid profile and blood glucose-lowering effects of cheonggukjang (CH) and red ginseng CH (RGCH) in 45 subjects (men:women -27:18; mean age, 44.9 +/- 3.1 years) with impaired fasting glucose (IFG). Subjects were randomly divided into three groups: control (starch, 2 g/day), CH (20 g/day), and RGCH (20 g/day). Each volunteer received his or her daily doses for 8 weeks. The supplementation with CH and RGCH significantly decreased the plasma total cholesterol about 30.0 mg/mL and 37.7 mg/mL, respectively, compared to the initial value. The plasma low-density lipoprotein-cholesterol concentration was also significantly reduced by 29.66% and 23.42% in the CH and RGCH groups, respectively, compared to the initial value. The concentration of plasma non-high-density lipoprotein-cholesterol (107.9 mg/mL) was significantly lowered in the RGCH group compared to the initial value (139.1 mg/mL). The level of erythrocyte thiobarbituric acid-reactive substances was significantly lowered in the CH (6.5 nmol/mL) and RGCH (6.6 nmol/mL) groups compared to the initial value (7.9 nmol/mL and 8.0 nmol/mL, respectively). The ratio of apolipoprotein B and apolipoprotein A-1 concentrations (2.5) was significantly reduced in the CH group compared to the initial value (3.0). The concentration of fasting blood glucose (FBG) was significantly lower in the CH-and RGCH-supplemented groups compared to the initial value. These results suggest that CH and RGCH can lower the FBG concentration and improve the plasma lipid profile in subjects with IFG.