Journal
JOURNAL OF MEDICINAL FOOD
Volume 14, Issue 1-2, Pages 108-113Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2009.1366
Keywords
fermented foods; human; lipids
Funding
- Ministry for Agriculture, Forestry and Fisheries
- Ministry of Education, Science and Technology, Republic of Korea [2009-0063409]
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This study was conducted to investigate the plasma lipid profile and blood glucose-lowering effects of cheonggukjang (CH) and red ginseng CH (RGCH) in 45 subjects (men:women -27:18; mean age, 44.9 +/- 3.1 years) with impaired fasting glucose (IFG). Subjects were randomly divided into three groups: control (starch, 2 g/day), CH (20 g/day), and RGCH (20 g/day). Each volunteer received his or her daily doses for 8 weeks. The supplementation with CH and RGCH significantly decreased the plasma total cholesterol about 30.0 mg/mL and 37.7 mg/mL, respectively, compared to the initial value. The plasma low-density lipoprotein-cholesterol concentration was also significantly reduced by 29.66% and 23.42% in the CH and RGCH groups, respectively, compared to the initial value. The concentration of plasma non-high-density lipoprotein-cholesterol (107.9 mg/mL) was significantly lowered in the RGCH group compared to the initial value (139.1 mg/mL). The level of erythrocyte thiobarbituric acid-reactive substances was significantly lowered in the CH (6.5 nmol/mL) and RGCH (6.6 nmol/mL) groups compared to the initial value (7.9 nmol/mL and 8.0 nmol/mL, respectively). The ratio of apolipoprotein B and apolipoprotein A-1 concentrations (2.5) was significantly reduced in the CH group compared to the initial value (3.0). The concentration of fasting blood glucose (FBG) was significantly lower in the CH-and RGCH-supplemented groups compared to the initial value. These results suggest that CH and RGCH can lower the FBG concentration and improve the plasma lipid profile in subjects with IFG.
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