Journal
JOURNAL OF MEDICINAL FOOD
Volume 14, Issue 10, Pages 1097-1106Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2010.1450
Keywords
anthocyanins; 1,1-diphenyl-2-picrylhydrazyl; fatty acid synthetase; interleukin-6; leptin; lipogenesis; purple sweet potato extract; 3T3-L1 adipocytes
Funding
- Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea [109114-03-1-HD120]
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The purpose of the current study was to determine the anti-obesity and anti-inflammatory effects of an extract of purple sweet potatoes (PSPs) on 3T3-L1 adipocytes. For this purpose, differentiated 3T3-L1 adipocytes were treated with a PSP extract at concentrations of 1,000, 2,000, and 3,000 mu g/mL for 24 hours. Then, we measured the changes in the sizes of the adipocytes, the secretion of leptin, and the mRNA/protein expression of lipogenic, inflammatory, and lipolytic factors after the treatment with the PSP extract. The PSP extract diminished leptin secretion, indicating that growth of fat droplets was suppressed. The extract also suppressed the expression of mRNAs of lipogenic and inflammatory factors and promoted lipolytic action. The antioxidative activity of the PSP extract was also measured using three different in vitro methods: 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity, ferric reducing ability potential assay, and chelating activity of transition metal ions. Taken together, our study shows that PSP extract has antilipogenic, anti-inflammatory, and lipolytic effects on adipocytes and has radical scavenging and reducing activity.
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