Journal
JOURNAL OF MEDICINAL FOOD
Volume 14, Issue 6, Pages 594-600Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/jmf.2010.1274
Keywords
cell adhesion; cell motility; cell spreading; cucumariosides; holothurians; immunomodulation; triterpene glycosides
Funding
- Presidium of the Russian Academy of Science [3531.2010.4]
- FE-BRAS [09-II-YO-05-002]
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Holothurian triterpene glycosides are known to possess multiple biological activities. Here we show that cucumarioside A(2)-2 from the Far-Eastern edible holothurian Cucumaria japonica possesses potent immunomodulatory properties. The present studies were done to determine if cucumarioside A(2)-2 would affect macrophage adhesion, spreading, and motility. Resident peritoneal macrophages, collected from BALB/c mice, were exposed in vitro to low concentrations of cucumarioside A(2)-2 and compared with appropriate controls. Results indicate that 0.02 mu g/mL cucumarioside A(2)-2 significantly enhanced macrophage morphology parameters and behavior. The glycoside stimulated these parameters by increasing the number of cells with increased adhesion properties as well as the spreading reaction and motility velocity by at least almost twofold. The data are discussed in terms of possible mechanisms underlying the immunomodulatory properties of cucumarioside A(2)-2.
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