4.4 Article

Hypoglycemic effect of Lentinus strigosus (Schwein.) fr. crude exopolysaccharide in streptozotocin-induced diabetic rats

Journal

JOURNAL OF MEDICINAL FOOD
Volume 11, Issue 3, Pages 513-517

Publisher

MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2007.0551

Keywords

exopolysaccharide; hypoglycemic effect; Lentinus strigosus

Funding

  1. Eskisehir Osmangazi University Research Foundation [200619016]
  2. Scientific Research and Application Centre (FBAM)
  3. Department of Biology, Eskisehir Osmangazi University

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This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal, STZ-induced diabetic, and EPS-treated diabetic rats. Following oral administration of FPS dosages for 7 days, the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS, at the dose of 150 mg/kg, exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P <.05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans.

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