Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 56, Issue 24, Pages 10171-10182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm4016137
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Funding
- Fonds der Chemischen Industrie (FCI, Germany)
- Swiss National Science Foundation (SNF)
- University of Zurich (UZH)
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In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.
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