Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 11, Pages 5110-5120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm300009q
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Funding
- Department of Science and Technology, Govt of India (DST) [SR/S5/MBD-01B/2007]
- Department of Atomic Energy (DAE), India
- CSIR, New Delhi
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A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.
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