Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 5, Pages 2437-2451Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm2005942
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Funding
- National Science Foundation [CHE-1057659]
- Alfred P. Sloan Foundation
- National Institutes of Health [CA118408]
- Department of Defense, US Army Medical Research [CA091380]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1057659] Funding Source: National Science Foundation
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This report describes the design and application of several distinct gold-containing indoles as anticancer agents. When used individually, all gold-bearing compounds display cytostatic effects against leukemia and adherent cancer cell lines. However, two gold-bearing indoles show unique behavior by increasing the cytotoxic effects of clinically relevant levels of ionizing radiation. Quantifying the amount of DNA damage demonstrates that each gold-indole enhances apoptosis by inhibiting DNA repair. Both Au(I)-indoles were tested for inhibitory effects against various cellular targets including thioredoxin reductase, a known target of several gold compounds, and various ATP-dependent kinases. While neither compound significantly inhibits the activity of thioreoxin reductase, both showed inhibitory effects against several kinases associated with cancer initiation and progression. The inhibition of these kinases provides a possible mechanism for the ability of these Au(I)-indoles to potentiate the cytotoxic effects of ionizing radiation. Clinical applications of combining Au(I)-indoles with ionizing radiation are discussed as a new strategy to achieve chemosensitization of cancer cells.
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