Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 6, Pages 2688-2701Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm201561r
Keywords
-
Categories
Ask authors/readers for more resources
Advanced leads of an imidazopyridine series of positive allosteric modulators of the metabotropic glutamate 2 (mGlu2) receptor are reported. The optimization of in vitro ADMET and in vivo pharmacokinetic properties led to the identification of 27o. With good potency and selectivity for the mGlu2 receptor, 270 affected sleep-wake architecture in rats after oral treatment, which we have previously shown to be indicative of mGlu2 receptor-mediated central activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available