Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 15, Pages 6980-6984Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm300749q
Keywords
-
Categories
Funding
- Grants-in-Aid for Scientific Research [22240091, 23300348] Funding Source: KAKEN
Ask authors/readers for more resources
To develop a boron carrier for practical purposes, new boron-containing amino acids with an undecahydro-closo-dodecaboranylthio ([(B12H11S)-B-10](2-)-) unit in the side chain of the a-amino acid have already been designed and synthesized. In the present paper, cytotoxicity, the incorporation amounts into tumor cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as boron carriers. Furthermore, the microdistribution of the amino acids in tumor cells was established.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available