Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 55, Issue 1, Pages 553-557Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm201023g
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Funding
- IISER Pune
- NISER Bhubaneshwar
- Department of Science and Technology (DST) India [R/FT/CS-89/2010]
- Council for Scientific and Industrial Research (CSIR)
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Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 mu M) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 mu M).
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