Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 1, Pages 401-405Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm100968b
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Funding
- CRISP
- MIUR Sostanze Naturali ed Analoghi Sintetici con Attivita Antitumorale, Rome, Italy
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The finding of new PXR modulators as potential leads for treatment of human disorders characterized by dysregulation of innate immunity and with inflammation is of wide interest In this paper, we report the identification of the first example of natural marine PXR agonists, solomonsterols A and B, from a Theonella swinhoei sponge The structures were determined by interpretation of NMR and ESIMS data, and the putative binding mode to PXR has been obtained through docking calculations
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