Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 16, Pages 5949-5953Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm200686d
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Funding
- EU Commission [Antimal-LSHP-CT-2005-18834]
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Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxides in only a few steps. The in vitro antiplasmodial potency of the peroxides was similar to, or greater than, that of the reference natural compound, and structure-activity relationship studies revealed several key structural requirements for activity and potency.
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