Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 11, Pages 3903-3925Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm2001986
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Funding
- Fonds der Chemischen Indutrie
- CIPS cluster in Munich
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Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.
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