4.7 Article

4-[18F]Fluoroglutamic Acid (BAY 85-8050), a New Amino Acid Radiotracer for PET Imaging of Tumors Synthesis and in Vitro Characterization

Journal

JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 1, Pages 406-410

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jm101068q

Keywords

-

Ask authors/readers for more resources

There is a high demand for tumor specific PET traceis in oncology imaging Besides glucose, certain amino acids also serve as energy sources and anabolic, precursors for tumors Therefore, F-18-labeled amino acids are interesting probes for tumor specific PET imaging As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[F-18]fluoro L-glutamic acid (BAY 85-8050) as a new specific PET tracer was established Cell-uptake studies revealed specific tumor cell accumulation

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available