Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 54, Issue 1, Pages 406-410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm101068q
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There is a high demand for tumor specific PET traceis in oncology imaging Besides glucose, certain amino acids also serve as energy sources and anabolic, precursors for tumors Therefore, F-18-labeled amino acids are interesting probes for tumor specific PET imaging As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[F-18]fluoro L-glutamic acid (BAY 85-8050) as a new specific PET tracer was established Cell-uptake studies revealed specific tumor cell accumulation
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